Best Antihistamine For Dogs With Skin Allergies (Reviews & Buying Guide)

Dogs are lively animals filled with curiosity. Running through allergen or getting stung by bees is a quite common scenario for dogs. These types of scenarios eventually lead to your dog with skin allergies.

Over-the-counter antihistamine treats human allergies. Dog skin allergies can be treated with antihistamine as well.

Treating your dog’s allergic symptoms by yourself is not recommended. Human dosage guidelines for antihistamine often does not work for dogs. It is why a vet’s guidance is essential.

With the proper guidance, you can treat your dog’s skin allergies with the proper dosage of antihistamines. And with the appropriate dosage of antihistamine, the allergic symptoms like rashes will start to soothe within an hour.

In this write-up, we will be discussing the best antihistamine for dogs with skin allergies. Each of these allergy medicines is formulated without toxic ingredients for dogs.

So, without further ado, let’s get started!

best antihistamine for dogs with skin allergies

Top 5 Antihistamine for Dogs with Skin Allergies: Table

Name Weight Package Dimension Price
Johnson & Johnson Benadryl Liqui-Gels Antihistamine 9.6 Ounces ‎ 6 x 6 x 10 inches See Price

Zesty Paws Allergy Immune Supplement for Dogs with antihistamine effects

2.5 Pounds 6 x 5 x 5 inches See Price

FurroLandia Allergy Relief Immune Supplement for Dogs

13.9 Ounces 4.25 x 3.62 x 3.27 inches See Price

PetHonesty Allergy Support Supplement for Dogs with Antihistamine Activity

13.12 Ounces 3.66 x 3.58 x 3.43 inches See Price

BiologicVET BioSKIN&COAT Natural Antihistamine for Dogs

14.08 Ounces

6.22 x 3.58 x 3.54 inches See Price

Reviews of The 5 Best Antihistamine For Dogs With Skin Allergies

1. Johnson & Johnson Benadryl Liqui-Gels Antihistamine Allergy Medicine

Benadryl is one of the most common antihistamine medicines that have outstanding benefit of keeping allergies in control for dogs. Benadryl Allergy Dye-Free Liqui-Gels by Johnson & Johnson is a dye-free gel that provides multi-system allergy and cold symptoms relief.

Diphenhydramine HCl is the main chemical ingredient used to control allergy symptoms like itching, rash, hay fever, sneezing, runny nose, itchy nose/eyes/throat and, the common cold.

Benadryl Liqui-Gels Antihistamine Allergy Medicine is mainly formulated for humans, but it also works well for your canine friends. It is a dye/additional color-free liquid gel capsule. It also temporarily ease the symptoms of hay fever and upper respiratory allergies.


Product Dimensions : ‎ 6 x 6 x 10 inches

Item Weight: 9.6 Ounces

Amount: 24 capsule/pack

Ingredients: Diphenhydramine HCl

Direction to Use:

  • 1 mg/ pound dog weight (one 25mg tablet/ 25lb dog).
  • Use 2 times daily.
  • Store between  
  • Avoid high humidity and heat
  • Protect from light.

Things We Like

  • This medicine works for dogs as an antihistamine.
  • Dye or additional color free
  • Works for allergy, cold, fever for humans as well as animals
  • Low price

Things We Don’t Like

  • It has some common side effects, i.e., drowsiness, dry mouth, urinary retention, hyper-salivation, rapid heart rate, etc.
  • You may need to consult a veterinarian if side effects occur.

>>Check Latest Price on Amazon<<

2. Zesty Paws Allergy Immune Supplement for Dogs with antihistamine effects

Zesty Paws Allergy Immune Supplement is a dietary supplement, not any medicine. It does not directly reduce histamine productions, but it increases the body’s immunity against allergy, thus reduce histamine release.

It has different natural ingredients (highly nutritious) such as salmon oil, fish oil, Epicor, digestive prebiotic & probiotic, Saccharomyces Cerevisiae, Coconut Glycerin, Flaxseed, Mixed Tocopherols, Palm Fruit Oil, Sunflower Lecithin, etc. Most of the natural ingredients are a rich source of Omega-3 fatty acids, EPA as well as DHA. Fish oil fatty acids and Omega-3 fatty acids can truly assist in reducing inflammation and build a healthy skin coat.

It is improved with Epicor that contains proteins, vitamins, fiber, and antioxidants. All these ingredients are clinically proven to support the immune defenses of the body.

Colostrum, another important ingredient, is a rich source of Omega-3 fatty acids, EPA, and DHA that develop antihistamine activities for dogs.  Zesty Paws Allergy Immune Supplement can reduce histamine productions for your dogs. So, I put forward to apply this antihistamine chews if your dog is suffering from itchy skin.

Zesty Paws Antihistamine for dogs


  • Dimensions: 6 x 5 x 5 inches
  • Weight: 2.5 Pounds
  • Quantity: 2 different bottles available containing 90 and 180 Count


Coconut Glycerin, Fructooligosaccharides, Mixed Tocopherols, Natural Flavors (from Oregano, Flaxseed and Plums), Palm Fruit Oil, Rosemary Extract, Sunflower Lecithin, Flaxseed, Lamb, Pea Flour, Powdered Cellulose etc.

Instructions to Use:

Size of Dogs Size of Dogs
Up to 25lbs 1 Chew/day
26-75lbs 2 Chews/day
Over 75lbs 3 Chews/day

Things We Like

  • Provides antihistamine activity (boost immunity thus reduce histamine production)
  • Supports gut health
  • Promotes skin health
  • Seasonal allergy support
  • Five strains probiotic blend
  • Omega 3 fatty acid rich salmon oil

Things We Don’t Like

  • No Cons

>> Check Latest Price on Amazon<<

3. FurroLandia Allergy Relief Immune Supplement for Dogs with Antihistamine Effect

FurroLandia Allergy Relief Immune Supplement is another dog supplement to our list with the best antihistamine activities for allergic dogs. This antihistamine supplement is made with various natural components in the absence of synthetic elements, preservatives and harmful dyes.

The FurroLandia antihistamine probiotics and prebiotics help digestion, thus improve gut health. In addition, the Omega-3 fatty acids from fish oils, etc., keep histamine reactions in control and can improve skin coats for your dogs.

I think you are worried about why this is one of the best antihistamines for your dogs with skin allergies? Although this is not a medicine, it has some natural healthy ingredients with nutritional values.  Let’s face it

Ingredients Functions
Colostrum Contains antibodies and white blood cells to boost immunity & fight against allergy.
Turmeric Anti-inflammatory and anti-oxidant that can help relieve allergy and itching.
Argan Oils It helps boost immunity and treat skin allergies with fatty acids.
Probiotics Contribute to a healthy gut for immunity strengths. 
FurroLandia antihistamine Allergy Relief Immune Supplement for Dogs


  • Dimensions: 4.25 x 3.62 x 3.27 inches
  • Weight: 13.9 Ounces
  • Quantity: 170 Chews


Colostrum, turmeric, licorice root, argan oil, probiotics, prebiotic, inulin, valerian root, fennel, rice flour, oat flour, natural bacon flavorings, deionized water, yeast, sunflower oil, organic vegetable blend, sunflower lecithin, apple cider vinegar, flaxseed meal, blackstrap  molasses, etc.

Instruction to Use

Size of Dogs Number of Chews
Under 10 lbs 1 chew/day
10 to 30 lbs 2 chews/day
30 to 50 lbs 3 chews/day
50 to 90 lbs 4 chews/day
90 lbs or more 5 chews/day

Things We Like

  • 100 natural components
  • No genetically modified organisms
  • It relieves seasonal, skin, and food allergies.
  • It has antihistamine activity

Things We Don’t Like

  • Unpleasant odor

>>Check Latest Ptice on Amazon<<

4. PetHonesty Allergy Support Supplement for Dogs with Antihistamine Activity

This antihistamine dog supplement comes in 3 flavors: salmon, chicken, and peanut butter, which allows you to choose from different alternatives. Some people have commented that their beloved dogs do not like some specific flavored chews. So three different flavorings of this product will give a solution to choose the best one that your dog will love.

If your dog is suffering from an unusual histamine response- the most day-to-day cause of a dog’s seasonal food allergies- you will need to provide a nutrient-rich supplement with antihistamine activity. 

PetHonesty Allergy Support Supplement comes with nutrient-rich constituents: colostrum, turmeric, probiotic, Alaskan salmon oils, etc., that controls histamine productions. In addition, colostrum, turmeric, salmon oil improves the body’s immunity against allergic reactions. 

This antihistamine chew contains wild Alaskan salmon oil, a rich source of omega-3fatty acids that improve skin health and immune system.  So you can try this antihistamine supplement for your canine having an irksome allergy. 

PetHonesty Antihistamine for Dogs


  • Dimensions: 3.66 x 3.58 x 3.43 inches
  • Weight: 13.12 Ounces
  • Quantity: 90 Chews


Turmeric, Salmon Oil, Colostrum, Probiotic Blend, Vitamin C + nutritious superfood base: sweet potato. Carrot & mushroom blend

Instruction To Use:

Size of Dogs Number of Chews
Up to 25lbs 1 Chew/day
26-75lbs 2 Chews/day
Over 75lbs 3 Chews/day

Things We Like:

  • Control unusual histamine production
  • Improves gut health of your dogs
  • Cure skin sore associated with seasonal allergies.
  • Healthy coat
  • Improves immune system
  • Helps dog having a seasonal allergy.

Things We Don’t Like

  • Some dogs refuse to eat for the first time. 

>>Check Latest Price on Amazon<<

5.BiologicVET BioSKIN&COAT Natural Antihistamine for Dogs

BiologicVET BioSKIN&COAT is a bioflavonoid-based antihistamine made with natural ingredients. It improves the immune system and maintains a typical histamine response to allergens, improving dogs’ healthy coat and skins.

A mixture of natural ingredients, i.e., organic, seed fiber, whole food, etc., makes it tasty and optimize nutrient bioavailability. The BioSKIN&COAT is also improved with biologically active ingredients containing essential Omega-3 fatty acids, Omega-6 fatty acids, DHA and EPA, etc. In addition, it has lignin-rich bio-fibers that act to stimulate nutrients absorption and support normal hormone production.

This antihistamine is mainly designed to ameliorate metabolic activity and the gastrointestinal tract of dogs and cats. So, you can find it as an effective antihistamine for your dogs suffering from skin allergies.  

BiologicVET BioSKIN&COAT Natural Antihistamine for Dogs


  • Dimensions: 3 sizes (3.6 x 3.6 x 3.4 inches; ‎ 6.22 x 3.58 x 3.54 inches ; 10.3 x 6.1 x 6.1 inches respectively)
  • Weight: 7.04 Ounces, 14.08 Ounces; 3.5 Pounds, respectively


MSM (Methylsulfonylmethane), Quercetin, Vitis vinifera, Bromelain, l-Cystine, Pancrelipase, Papain, Protease, Zinc, etc

Instruction To Use:

  • Half scoop (tbsp.) (2.5 g) /10 lb of body weight.
  • Maximum of 6 scoops daily.
  • 5 g scoop included (equals 1 Tbsp) if taken full stomach.

Things We Like:

  • Maintains normal histamine level
  • Supports skin health and coat
  • Powder format for optimum absorption
  • Natural nutrient-rich ingredients
  • Meet conditions of National Animal Supplement Council.
  • Free of artificial flavor, colors, binders, etc

Things We Don’t Like

  • No Cons found

>> Check Latest Price on Amazon<<

How To Choose The Best Antihistamine For Dogs With Skin Allergies?

When it comes to choosing the best antihistamine for dogs, the most important point is always the ingredients. An ideal medication for dogs should not be formulated with toxic substances to dogs.

Here are some of the key points you should look at in your dog’s allergy medication:

Formulated For Dogs:

Antihistamines or antihistamine supplements formulated for dogs are always recommended to use. Over-the-counter antihistamines can be used to treat dog skin allergies, but they will not be as helpful to soothe the redness and irritation.

Some over-the-counter antihistamines formulated for the human body can be toxic to dogs. Well-known over-the-counter antihistamines like Benadryl are available in various formulas. But all formulas are not safe for your dog either.

Antihistamine poisoning or overdose can occur by using medication that is not formulated for dogs but humans.

 Free Of Toxic Substances:

As we have previously stated, many over-the-counter antihistamines are formulated with substances that can be harmful to dogs. If you are planning on treating your dog’s skin allergies with common allergy medication like Benadryl or Zyrtec, then reach out to a veterinarian first.

Antihistamines like Benadryl are available in many formulas. You should not administer antihistamines with decongestants to your dog.

If you are unsure whether your antihistamine has decongestants or not, check out the label. If the name of the medication is accompanied by a “-D”, then it has decongestants.


Omega-3 fatty acids, antioxidants, etc., can help soothe the rashes and inflammation in your dogs’ skin within an hour of taking the medication.

If your dog has been suffering from an allergy for a long time, then feeding him allergy immune supplements with antioxidants and omega 3 will boost the recovery.

The fatty acids of Omega 3 will soothe the dry and red skin. Antioxidants will soothe the itchiness. Along with this, antioxidants and probiotics in the supplements will boost your dog’s immune system.

Made With Natural Ingredients:

If you are feeding your dog allergy immune supplements, then be sure to opt for a supplement made with natural ingredients.

Many supplements use artificial flavors, synthetic colors, and preservatives to enhance the supplements, leading to more health complications for your dog.

Frequently Asked Questions:

Q1. Why dog’s body produces histamine?

Any foreign particles like pollen, dust, dandruff, etc., when coming in touch with mucus membranes of your dog’s mouth, nose, lungs, throat, stomach, and intestines, activate the release of histamines.

If your dog is suffering from allergies, histamine can quickly be released from red blood cells into the bloodstream as allergies lower the body’s immunity. Thus allergic dog produces more histamine, resulting in itching over the body.  

Q2. What does histamine do?

Histamine is a type of chemical produced from red blood cells that stimulate nerve for itching.

How do antihistamine chews cure itching?

Most antihistamine chews contain nutrients rich natural ingredients which contain Omega-3 fatty acids, EPA, DHA, etc. These essential nutrients improve the body’s immune system and control histamine production. It also improves skin health and skin coat. Thus cures itching in the dogs.


These medications were our top picks for the best antihistamine for dogs with skin allergies.

As we have previously mentioned, administering antihistamine to your dogs without consulting a veterinarian is not recommended by us.

Antihistamine overdose can lead to terrible aftereffects. If you would like to keep your dog on allergy immune supplements, consulting a veterinarian before is recommended. Allergy immune supplements can treat long-term allergies without harming the dog’s health in other ways.

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